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Dichloromethane → HCID 178445738、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | N-Iodosuccinimide | HCID 120273 | — |
| 反応物 | HCID 178445732 | HCID 178445732 | — |
| 触媒 | Zirconium chloride (ZrCl4), (T-4)- | HCID 9856075 | — |
| 生成物 | HCID 178445738 | HCID 178445738 | 86% |
反応手順
A mixture of (R)-4-(6-(cis-4-butylcyclohexyloxy)naphthalen-2-yl)-4-methyloxazolidin-2-one (Example 5, 113.2 mg, 0.0002967 mol), N-iodosuccinimide (74.8 mg, 0.000332 mol) and zirconium tetrachloride (10 mg, 0.000044 mol) in methylene chloride (2.43 mL, 0.0380 mol) was heated to reflux under argon in a vial overnight. The precipitate was filtered off and the residue was purified with Isco column eluted with EtOAc in hexane from 0 to 40% to give the product as a solid (128.9 mg, 86% yield). NMR showed identity.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08546359B2 |
| 出典データセット | uspto-grants-2013_10 |
| ORD ID | ord-08153987430648df98ee0f40a24e18e0 |
| 出典メモ | uspto-grants-2013_10 |