HCID 71060655、化合物 → 1-Oxo-4-pyridin-3-yl-2,7-diaza-spiro[4.5]decane-7-carboxylic acid tert-butyl ester

HRID 1036722ノート

反応式

HRID 1036722 の反応式
C([O:3][C:4]([C:6]1([CH:19]([C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)[CH2:20][NH2:21])[CH2:11][CH2:10][CH2:9][N:8]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:7]1)=O)C>C1(C)C=CC=CC=1>[C:15]([O:14][C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C:6]2([C:4](=[O:3])[NH:21][CH2:20][CH:19]2[C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)[CH2:7]1)=[O:13])([CH3:16])([CH3:17])[CH3:18]

参加物

3

反応物 1

HCID 71060655HCID 71060655、化合物

生成物 1

HCID 710603511-Oxo-4-pyridin-3-yl-2,7-diaza-spiro[4.5]decane-7-carboxylic acid tert-butyl ester

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 3-(2-Amino-1-pyridin-3-yl-ethyl)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (2.5 g, 6.6 mmol) in toluene (21 ml) was heated at reflux overnight. The resulting mixture was concentrated in vacuo and the residue was purified by chromatography on silica eluting with 0-10% MeOH in DCM to afford the individual diastereomers as white solids:

後処理

  1. temperatureat reflux overnight
  2. concentrationThe resulting mixture was concentrated in vacuo
  3. customthe residue was purified by chromatography on silica eluting with 0-10% MeOH in DCM
  4. customto afford the individual diastereomers as white solids

出典と根拠

ORDレコード
ord-9bb109a5bd184ddf9cd0ccd46232f26a
出典データセット
uspto-grants-2013_10
特許番号
US08546416B2

反応ノート

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