Hydrochloric Acid → HCID 59557972、化合物
反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[C:20]([N+:21]([O-:23])=[O:22])=[C:19]([NH:24][C:25]3[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=3)[N:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[CH3:34][S:31]([C:28]1[CH:29]=[CH:30][C:25]([NH:24][C:19]2[C:20]([N+:21]([O-:23])=[O:22])=[C:15]([NH:14][CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[N:16]=[CH:17][N:18]=2)=[CH:26][CH:27]=1)(=[O:33])=[O:32]参加物
4
反応条件
- 温度
- 40 °C
実験手順
General Deprotection Procedure: A mixture of Compound B1 and 4 M HCl in dioxane was stirred at 40° C. overnight and concentrated. Excess HCl was evaporated with isopropyl alcohol provided Compound B2 as yellow solid (261 mg, 97%). 1H NMR (400 MHz CDCl3) δ (ppm): 10.9 (s, 1H), 8.96 (d,2H), 8.17 (s,1H), 7.84 (d, 4H), 4.40-4.37 (m,1H), 3.25-3.22 (m,2H), 3.16 (s,3H), 3.01-2.93 (m, 2H), 2.04-2.01 (m,2H), 1.88-1.78 (m,2H). Exact mass calculated for C16H20N6O4S 392.13, LCMS (ESI) m/z 393.1 (M+H+, 100%).