Ethyl 4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylate → 4-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylic acid

HRID 1036993ノート

反応式

HRID 1036993 の反応式
ClC1C=C(C2SC(C(O)=O)=CC=2C2C=CC=C(C#N)C=2)C=C(F)C=1.[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[CH:34]=[C:35]([C:46]([O:48]CC)=[O:47])[S:36][C:37]=2[C:38]2[CH:43]=[C:42]([F:44])[CH:41]=[C:40]([Cl:45])[CH:39]=2)[CH:29]=[CH:30][C:31]=1[F:32]>>[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[CH:34]=[C:35]([C:46]([OH:48])=[O:47])[S:36][C:37]=2[C:38]2[CH:43]=[C:42]([F:44])[CH:41]=[C:40]([Cl:45])[CH:39]=2)[CH:29]=[CH:30][C:31]=1[F:32]

参加物

3

反応物 2

HCID 58066743Ethyl 4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylateHCID 580667575-(3-Chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

生成物 1

HCID 580667454-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylic acid

実験手順

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 19A starting with the compound from Example 12A. The organic phase is concentrated and purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate/ethyl acetate:methanol 1:1 gradient) on silica gel. 0.43 g (100% of theory) of the title compound are obtained.

後処理

  1. concentrationThe organic phase is concentrated
  2. custompurified by flash chromatography (mobile phase: cyclohexane/ethyl acetate/ethyl acetate:methanol 1:1 gradient) on silica gel

出典と根拠

ORDレコード
ord-5b488de93749427cbf16c75da2d35efd
出典データセット
uspto-grants-2013_10
特許番号
US08546438B2

反応ノート

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