{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → {1-[4-(8-Bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

HRID 1037278ノート

反応式

HRID 1037278 の反応式
[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24](F)[CH:25]=4)[O:20][C:19]=3[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[Br:37]C1C=CC=C2C=1OC(C1C=CC=CC=1)=C(I)C2=O>>[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:27](=[O:28])[C:26]4[C:21](=[C:22]([Br:37])[CH:23]=[CH:24][CH:25]=4)[O:20][C:19]=3[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 67067635{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl esterHCID 670677418-Bromo-3-iodo-2-phenyl-chromen-4-one

生成物 1

HCID 67067700{1-[4-(8-Bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester収率 67%

実験手順

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 8-bromo-3-iodo-2-phenyl-chromen-4-one was reacted to give the title compound (73 mg, 67%). 1H NMR (400 MHz, CDCl3): δ 8.24 (dd, J=7.9 and 1.6 Hz, 1H), 7.94 (dd, J=7.7 and 1.5 Hz, 1H), 7.50 (d, J=7.0 Hz, 2H), 7.39 (d, J=8.2 Hz, 2H), 7.36-7.19 (m, 6H), 5.06 (s, 1H), 2.60-2.47 (m, 4H), 2.14-2.01 (m, 1H), 1.91-1.77 (m, 1H), 1.37 (bs, 9H).

後処理

  1. customwas reacted

出典と根拠

ORDレコード
ord-cb66d73159724ebf9b84bf772467da6e
出典データセット
uspto-grants-2013_10
特許番号
US08546376B2

反応ノート

読み込み中…