3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-8-bromo-2-phenyl-chromen-4-one

HRID 1037279ノート

反応式

HRID 1037279 の反応式
NC1(C2C=CC(C3C(=O)C4C(=CC=C(F)C=4)OC=3C3C=CC=CC=3)=CC=2)CCC1.C(OC(=O)[NH:36][C:37]1([C:41]2[CH:46]=[CH:45][C:44]([C:47]3[C:56](=[O:57])[C:55]4[C:50](=[C:51]([Br:58])[CH:52]=[CH:53][CH:54]=4)[O:49][C:48]=3[C:59]3[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=3)=[CH:43][CH:42]=2)[CH2:40][CH2:39][CH2:38]1)(C)(C)C>>[NH2:36][C:37]1([C:41]2[CH:42]=[CH:43][C:44]([C:47]3[C:56](=[O:57])[C:55]4[C:50](=[C:51]([Br:58])[CH:52]=[CH:53][CH:54]=4)[O:49][C:48]=3[C:59]3[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=3)=[CH:45][CH:46]=2)[CH2:38][CH2:39][CH2:40]1

参加物

3

反応物 2

HCID 510305983-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-oneHCID 67067700{1-[4-(8-Bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

生成物 1

HCID 510298623-[4-(1-Amino-cyclobutyl)-phenyl]-8-bromo-2-phenyl-chromen-4-one収率 86%

実験手順

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(8-bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (25 mg, 86%). 1H NMR (400 MHz, CDCl3): δ 8.20 (dd, J=7.9 and 1.5 Hz, 1H), 7.91 (dd, J=7.6 and 1.5 Hz, 1H), 7.50-7.45 (m, 2H), 7.38-7.16 (m, 8H), 2.59-2.49 (m, 2H), 2.23-1.97 (m, 3H), 1.80-1.68 (m, 1H). LCMS (Method E): RT=3.91 min, [M+H]+=446/448.

後処理

  1. customwas reacted

出典と根拠

ORDレコード
ord-4b12cf9ad6d24cc29863c9b02d31172f
出典データセット
uspto-grants-2013_10
特許番号
US08546376B2

反応ノート

読み込み中…