関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Naltrexone Base | HCID 21159611 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Naltrexone Hydrochloride | HCID 5485201 | — |
反応手順
70 kg Naltrexone base is taken in 210 Lit DM water and pH was adjusted to ˜2.0 with Conc. HCl and heated to 70-75° C. to get clear solution, filtered to make particle free and slowly cooled to 2-5° C. in 6-8 hrs period, filtered and then dried. The base was generated from filtrate by treatment with sodium hydroxide and converted to HCl salt by repeating the above mentioned process. Yield: 59.8 kg
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08546572B2 |
|---|
| 出典データセット | uspto-grants-2013_10 |
|---|
| ORD ID | ord-255dff4051a1443da45aa8f55e091af9 |
|---|
| 出典メモ | uspto-grants-2013_10 |
|---|
