Diethylamine → 2-bromo-N,N-diethyl-4,5-difluorobenzamide
反応式
[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH2:13]([NH:15][CH2:16][CH3:17])[CH3:14]>C(Cl)Cl>[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([N:15]([CH2:16][CH3:17])[CH2:13][CH3:14])=[O:5]参加物
4
実験手順
1.05 g of 2-bromo-4,5-difluorobenzoyl chloride in 5 ml of DCM are added dropwise with stirring to a solution of 846.9 μl of diethylamine in 5 ml of DCM. The mixture is subsequently stirred at RT for 1 h. The mixture is then extracted a number of times against water (pH 9), the organic phase is dried and purified by column chromatography.
後処理
- extractionThe mixture is then extracted a number of times against water (pH 9)
- customthe organic phase is dried
- custompurified by column chromatography
出典と根拠
- ORDレコード
- ord-073503cc5e7d49dd9f6bbd5e57765372
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08546565B2
反応ノート
読み込み中…