2-Bromoethyl methyl ether → 4-(4-chlorophenyl)-3-(2-methoxyethyl)-5-methyl-3H-thiazol-2-ylideneamine hydrobromide

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([NH2:14])[S:11][C:12]=2[CH3:13])=[CH:4][CH:3]=1.[CH3:15][O:16][CH2:17][CH2:18][Br:19]>>[BrH:19].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]([CH2:18][CH2:17][O:16][CH3:15])[C:10](=[NH:14])[S:11][C:12]=2[CH3:13])=[CH:6][CH:7]=1

参加物

反応物 2

HCID 809722-Bromoethyl methyl ether

HCID 6675742-Amino-4-(4-chlorophenyl)-5-methylthiazole

生成物 1

HCID 686236114-(4-chlorophenyl)-3-(2-methoxyethyl)-5-methyl-3H-thiazol-2-ylideneamine hydrobromide

実験手順

A mixture of 4-(4-chlorophenyl)-5-methyl-thiazol-2-ylamine (420 mg, 1.87 mmol) and 2-bromoethyl methyl ether (600 μL, 6.40 mmol) was processed according to the method of Example 12A to provide the title compound: MS (DCI/NH3) m/z 283 (M+H)+.

出典と根拠

ORDレコード: ord-93e2d6d297c143fc9b4394467e7124f0
出典データセット: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08546583B2

反応ノート

読み込み中…