2,1,3-Benzoxadiazol-4(5H)-one, 5-bromo-6,7-dihydro- → 4,5-Dihydro[1,3]thiazolo[4,5-e][2,1,3]benzoxadiazol-7-amine hydrobromide

HRID 1037851ノート

反応式

HRID 1037851 の反応式
[Br:1][CH:2]1[C:10](=O)[C:6]2=[N:7][O:8][N:9]=[C:5]2[CH2:4][CH2:3]1.[NH2:12][C:13]([NH2:15])=[S:14]>C(O)C>[BrH:1].[N:7]1[O:8][N:9]=[C:5]2[CH2:4][CH2:3][C:2]3[S:14][C:13]([NH2:15])=[N:12][C:10]=3[C:6]=12

参加物

4

反応物 2

HCID 5729162,1,3-Benzoxadiazol-4(5H)-one, 5-bromo-6,7-dihydro-HCID 2723790Thiourea

生成物 1

HCID 866189084,5-Dihydro[1,3]thiazolo[4,5-e][2,1,3]benzoxadiazol-7-amine hydrobromide収率 90%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

To a solution of commercially available 5-bromo-6,7-dihydro-5H-benzo[1,2,5]oxadiazol-4-one (1.1 g, 5.1 mmol) in absolute ethanol (60 mL) was added thiourea. The reaction mixture was stirred at 60° C. for overnight and then concentrated. The residue was triturated in hexanes to afford 1.3 g (90%) of the title compound MS (ESI+) m/z 195 (M+H)+.

後処理

  1. concentrationconcentrated
  2. customThe residue was triturated in hexanes

出典と根拠

ORDレコード
ord-c95b0ed29fda43e196dcc79686db63e6
出典データセット
uspto-grants-2013_10
特許番号
US08546583B2

反応ノート

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