2-Bromoethyl methyl ether → 1-(2-methoxyethyl)-6,7-dihydro-1H-pyrano[4,3-d]thiazol-2(4H)-imine hydrobromide

反応式

[N:1]1[C:5]2[CH2:6][CH2:7][O:8][CH2:9][C:4]=2[S:3][C:2]=1[NH2:10].[CH3:11][O:12][CH2:13][CH2:14][Br:15]>>[BrH:15].[CH3:11][O:12][CH2:13][CH2:14][N:1]1[C:5]2[CH2:6][CH2:7][O:8][CH2:9][C:4]=2[S:3][C:2]1=[NH:10]

参加物

反応物 2

HCID 809722-Bromoethyl methyl ether

HCID 222244484H,6H,7H-pyrano(4,3-d)(1,3)thiazol-2-amine

生成物 1

HCID 686233401-(2-methoxyethyl)-6,7-dihydro-1H-pyrano[4,3-d]thiazol-2(4H)-imine hydrobromide

実験手順

A mixture of product of Example 218A (1.0 g, 6.4 mmol) and 2-bromoethyl methyl ether (3.0 mL, 32.0 mmol) was processed according to the method of Example 2A to afford the title compound: MS (LC/MS) m/z 213 (M+H)+.

出典と根拠

ORDレコード: ord-cdfa9e282019414e916bc04b4442f9c6
出典データセット: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08546583B2

反応ノート

読み込み中…