Bromine → 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine

HRID 1038121ノート

反応式

HRID 1038121 の反応式
[N:1]1([C:6]2[N:11]=[CH:10][CH:9]=[CH:8][N:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[Br:12]Br>C(O)(=O)C>[Br:12][C:4]1[CH:3]=[N:2][N:1]([C:6]2[N:7]=[CH:8][CH:9]=[CH:10][N:11]=2)[CH:5]=1

参加物

4

反応物 2

HCID 24408BromineHCID 111707712-(1H-Pyrazol-1-yl)pyrimidine

生成物 1

HCID 457897012-(4-Bromo-1H-pyrazol-1-yl)pyrimidine収率 85%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

To a solution of 2-pyrazol-1-yl-pyrimidine (0.55 g, 3.7 mmol) in acetic acid (5 mL) was added bromine (1.2 g, 7.5 mmol) in acetic acid (3 mL) dropwisely. After addition, the reaction mixture was stirred at room temperature overnight. After removed the acetic acid, the crude product was purified using column chromatography (2% methanol in dichloromethane) to give 0.7 g of pure product in 85% yield. MS (ESMS, M+H 225).

後処理

  1. additionAfter addition
  2. customAfter removed the acetic acid
  3. customthe crude product was purified

出典と根拠

ORDレコード
ord-19f31f338b3a44819c22eb0230e11faa
出典データセット
uspto-grants-2013_10
特許番号
US08546404B2

反応ノート

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