Water → (2-Bromo-4-methoxy-phenyl)-(4-ethyl-phenyl)-methanone

HRID 1038346

反応式

HRID 1038346 の反応式
[CH3:1][O-:2].[Na+].[Br:4][C:5]1[CH:10]=[C:9](F)[CH:8]=[CH:7][C:6]=1[C:12]([C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=1)=[O:13].O>CN(C=O)C>[Br:4][C:5]1[CH:10]=[C:9]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[C:12]([C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=1)=[O:13]

参加物

5

反応物 3

HCID 962WaterHCID 10942334Sodium Methoxide2 回HCID 43338337(2-Bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone

生成物 1

HCID 58385812(2-Bromo-4-methoxy-phenyl)-(4-ethyl-phenyl)-methanone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Sodium methoxide (10.5 g) is added portionwise to (2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone (43.0 g) dissolved in DMF (200 mL). The solution is stirred overnight, before another portion of sodium methoxide (5.5 g) is added. After another 3 h of stirring, water is added and the resulting mixture is extracted with ethyl acetate. The organic phase is dried (sodium sulphate), the solvent is removed and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1).

後処理

  1. additionis added
  2. extractionthe resulting mixture is extracted with ethyl acetate
  3. dry with materialThe organic phase is dried (sodium sulphate)
  4. customthe solvent is removed
  5. customthe residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1)

出典と根拠

ORDレコード
ord-b354e4188c2e4cc2a8d1df8d6c944858
出典データセット
uspto-grants-2013_10
特許番号
US08551957B2

関連ノート

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