Potassium Carbonate → 2-(4-{5-[1,1,1,3,3,3-Hexafluoro-2-(4-methoxybenzyloxy)propan-2-yl]-4-propylpyridin-2-yl}piperazin-1-yl)ethanol

HRID 1038514ノート

反応式

HRID 1038514 の反応式
C([O:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[C:17]([CH2:19][CH2:20][CH3:21])[C:16]([C:22]([O:31][CH2:32][C:33]3[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=3)([C:27]([F:30])([F:29])[F:28])[C:23]([F:26])([F:25])[F:24])=[CH:15][N:14]=2)[CH2:9][CH2:8]1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[F:25][C:23]([F:24])([F:26])[C:22]([C:16]1[C:17]([CH2:19][CH2:20][CH3:21])=[CH:18][C:13]([N:10]2[CH2:11][CH2:12][N:7]([CH2:6][CH2:5][OH:4])[CH2:8][CH2:9]2)=[N:14][CH:15]=1)([O:31][CH2:32][C:33]1[CH:34]=[CH:35][C:36]([O:39][CH3:40])=[CH:37][CH:38]=1)[C:27]([F:30])([F:29])[F:28]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 866471792-(4-{5-[1,1,1,3,3,3-Hexafluoro-2-(4-methoxybenzyloxy)propan-2-yl]-4-propylpyridin-2-yl}piperazin-1-yl)ethyl acetate

生成物 1

HCID 866471802-(4-{5-[1,1,1,3,3,3-Hexafluoro-2-(4-methoxybenzyloxy)propan-2-yl]-4-propylpyridin-2-yl}piperazin-1-yl)ethanol収率 47%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-(4-{5-[1,1,1,3,3,3-Hexafluoro-2-(4-methoxybenzyloxy)propan-2-yl]-4-propylpyridin-2-yl}piperazin-1-yl)ethyl acetate (479 mg) was dissolved in methanol (2.3 mL), added potassium carbonate (127 mg, 0.722 mmol), and the mixture was stirred at room temperature for 0.5 hours. The reaction solution was concentrated in vacuo. The obtained residue was purified by silica-gel column chromatography (chloroform/methanol). The title compound (117 mg (yield 47%)) was obtained as a yellow oil.

後処理

  1. concentrationThe reaction solution was concentrated in vacuo
  2. customThe obtained residue was purified by silica-gel column chromatography (chloroform/methanol)

出典と根拠

ORDレコード
ord-05a5d8d831ed420085abd5451819a7d8
出典データセット
uspto-grants-2013_10
特許番号
US08551985B2

反応ノート

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