1,3-Dichloro-2-isocyanatobenzene → 1-(2,6-Dichloro-phenyl)-3-[6-(4-fluoro-phenylamino)-pyrimidin-4-yl]-urea

HRID 1038689ノート

反応式

HRID 1038689 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[C:13]([NH2:15])[N:12]=[CH:11][N:10]=2)=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:18]=1[N:24]=[C:25]=[O:26]>O1CCOCC1>[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:18]=1[NH:24][C:25]([NH:15][C:13]1[CH:14]=[C:9]([NH:8][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[N:10]=[CH:11][N:12]=1)=[O:26]

参加物

4

反応物 2

HCID 6045371,3-Dichloro-2-isocyanatobenzeneHCID 66669888N-(4-Fluoro-phenyl)-pyrimidine-4,6-diamine

生成物 1

HCID 577103381-(2,6-Dichloro-phenyl)-3-[6-(4-fluoro-phenylamino)-pyrimidin-4-yl]-urea

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
80 °C

実験手順

A suspension of N-(4-fluoro-phenyl)-pyrimidine-4,6-diamine (408.4 mg, 2 mmol), 2,6-dichlorophenyl isocyanate (413.6 mg, 2.2 mmol) in dry dioxane (5 mL) is shaken for 14 h at 80° C. After cooling to 5° C. the suspension is filtered, the residue washed with half-saturated K2CO3 solution, H2O and acetone and dried in vacuo.

後処理

  1. temperatureAfter cooling to 5° C. the suspension
  2. filtrationis filtered
  3. washthe residue washed with half-saturated K2CO3 solution, H2O and acetone
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-a08985a5ca8044b6a02b7f970436d2c3
出典データセット
uspto-grants-2013_10
特許番号
US08552002B2

反応ノート

読み込み中…