5-Isocyanato-1,2,3-trimethoxybenzene → 1-[6-(3-Chloro-phenylamino)-pyrimidin-4-yl]-3-(3,4,5-trimethoxy-phenyl)-urea

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[CH:14]=[C:13]([NH2:15])[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([N:28]=[C:29]=[O:30])[CH:21]=[C:22]([O:26][CH3:27])[C:23]=1[O:24][CH3:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:10]=[CH:11][N:12]=[C:13]([NH:15][C:29]([NH:28][C:20]3[CH:19]=[C:18]([O:17][CH3:16])[C:23]([O:24][CH3:25])=[C:22]([O:26][CH3:27])[CH:21]=3)=[O:30])[CH:14]=2)[CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 5177665-Isocyanato-1,2,3-trimethoxybenzene

HCID 66669982N~4~-(3-chlorophenyl)pyrimidine-4,6-diamine

生成物 1

HCID 577104271-[6-(3-Chloro-phenylamino)-pyrimidin-4-yl]-3-(3,4,5-trimethoxy-phenyl)-urea

実験手順

The title compound is prepared analogously as described in Example 127 from N-(3-chloro-phenyl)-pyrimidine-4,6-diamine and 3,4,5-trimethoxyphenyl isocyanate.

出典と根拠

ORDレコード: ord-eac548e3ccf64e398072bb75d3955d75
出典データセット: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08552002B2

反応ノート

読み込み中…