Thiophosgene → N-Benzo[1,3]dioxol-5-ylmethyl-thioformamide chloride

HRID 1038959

反応式

HRID 1038959 の反応式
[CH2:1]([NH2:11])[C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1.[C:12](Cl)([Cl:14])=[S:13]>ClCCl>[Cl-:14].[O:7]1[C:8]2[CH:9]=[CH:10][C:2]([CH2:1][NH:11][CH:12]=[S:13])=[CH:3][C:4]=2[O:5][CH2:6]1

参加物

4

反応物 2

HCID 10040ThiophosgeneHCID 75799Benzo-1,3-dioxole-5-methylamine

生成物 1

HCID 86601006N-Benzo[1,3]dioxol-5-ylmethyl-thioformamide chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of piperonylamine (0.1 mL, 0.77 mmol) in dichloromethane (20 mL) was slowly added thiophosgene (0.06 mL, 0.83 mmol) under cooling with an ice bath. After the reaction mixture was stirred for four hours at room temperature, it was washed with water and brine, dried over anhydrous sodium sulfate, filtered, evaporated and dried under vacuum; and the product was used immediately for the next reaction.

後処理

  1. temperatureunder cooling with an ice bath
  2. washit was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customdried under vacuum
  7. customand the product was used immediately for the next reaction

出典と根拠

ORDレコード
ord-4dec44f39b5c4ecea65cb5ed984f11d5
出典データセット
uspto-grants-2013_10
特許番号
US08552018B2

関連ノート

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