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3-Bromo-2-fluoro-5-methylpyridine → 8-(2-Fluoro-5-methylpyridin-3-yl)-2-(4-(trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Bromo-2-fluoro-5-methylpyridine | HCID 21816563 | — |
| 反応物 | 2-(4-(Trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one | HCID 66742759 | — |
| 生成物 | 8-(2-Fluoro-5-methylpyridin-3-yl)-2-(4-(trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one | HCID 56655688 | — |
反応手順
The title compound was prepared in analogy to example 1 step D from a mixture of 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 1 step C) and 3-bromo-2-fluoro-5-methylpyridine. Light yellow solid. MS (ESI): 424.1 (MH+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08552024B2 |
| 出典データセット | uspto-grants-2013_10 |
| ORD ID | ord-d3524c3bf54e48c0860a59de9fdffb56 |
| 出典メモ | uspto-grants-2013_10 |