Water → 5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

HRID 1039061ノート

反応式

HRID 1039061 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH:15]=[N:14][CH:13]=[N:12]1.C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C=O)C>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)=[N:3][CH:4]=1)([O-:10])=[O:9]

参加物

6

反応物 4

HCID 962WaterHCID 92571H-1,2,4-TriazoleHCID 10796Cesium carbonateHCID 952642-Fluoro-5-nitropyridine

生成物 1

HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2-fluoro-5-nitropyridine (0.5 g, 3.38 mmol), 1,2,4-triazole (0.22 g, 3.22 mmol) were added in DMF (6.4 mL), then cesium carbonate (3.14 g, 9.65 mmol) was added. The reaction was run at room temperature for 30 minutes. Water (50 mL) was added and product fell out of the solution. The solution was filtered and the solid was rinsed with ethyl acetate/water (1:1, 20 mL×2), hot hexane (20 mL) to give the title compound as a white solid.

後処理

  1. filtrationThe solution was filtered
  2. washthe solid was rinsed with ethyl acetate/water (1:1, 20 mL×2), hot hexane (20 mL)

出典と根拠

ORDレコード
ord-f57ebb80bb79433bb24a6b091ca610d5
出典データセット
uspto-grants-2013_10
特許番号
US08552022B2

反応ノート

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