5-[5-(2-Acetylamino-phenyl)-isoxazol-3-yl]-pentanoic acid ethyl ester → 5-[5-(2-Acetylamino-phenyl)-isoxazol-3-yl]-pentanoic acid
反応式
C([O:3][C:4](=[O:24])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[CH:13]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[NH:20][C:21](=[O:23])[CH3:22])[O:11][N:10]=1)C>Cl>[C:21]([NH:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:12]1[O:11][N:10]=[C:9]([CH2:8][CH2:7][CH2:6][CH2:5][C:4]([OH:24])=[O:3])[CH:13]=1)(=[O:23])[CH3:22]参加物
3
実験手順
Add 2N HCl solution (100 mL, in water) to 5-[5-(2-acetylamino-phenyl)-isoxazol-3-yl]-pentanoic acid ethyl ester (4.02 g, 12.2 mmol) and heat to reflux under N2 overnight Cool to room temperature and concentrate to afford the title compound (3.46 g, 96% yield). MS (IS) 259 (M−1)−.
後処理
- temperatureheat
- temperatureto reflux under N2 overnight
- concentration