Triethylamine → 3-(2-Chlorophenyl)-2-(2-ethylcarbamoylethyl)-5,7-dimethyl-4-oxo-3,4-dihydroquinazoline-6-carboxylic Acid Ethyl Ester

HRID 1039365ノート

反応式

HRID 1039365 の反応式
[CH2:1]([O:3][C:4](=[O:26])[C:5]1[C:13]([CH3:14])=[CH:12][C:11]([NH:15][C:16](=O)[CH2:17][CH2:18][C:19]([O:21]CC)=O)=[C:7]([C:8]([OH:10])=O)[C:6]=1[CH3:25])[CH3:2].C(OC(=O)[C:31]1[C:39](C)=[CH:38][C:37]([NH2:41])=[C:33](C(O)=O)[C:32]=1C)C.[CH2:44]([N:46](CC)CC)[CH3:45].C(C(CC(Cl)=O)C([Cl:56])=O)C>ClCCl>[CH2:1]([O:3][C:4]([C:5]1[C:6]([CH3:25])=[C:7]2[C:11](=[CH:12][C:13]=1[CH3:14])[N:15]=[C:16]([CH2:17][CH2:18][C:19](=[O:21])[NH:46][CH2:44][CH3:45])[N:41]([C:37]1[CH:38]=[CH:39][CH:31]=[CH:32][C:33]=1[Cl:56])[C:8]2=[O:10])=[O:26])[CH3:2]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 126858402-Amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acidHCID 218646082-Ethylbutanedioyl dichlorideHCID 865975834-(3-Ethoxycarbonylpropionylamino)-2,6-dimethylisophthalic acid 1-ethyl ester

生成物 1

HCID 115906083-(2-Chlorophenyl)-2-(2-ethylcarbamoylethyl)-5,7-dimethyl-4-oxo-3,4-dihydroquinazoline-6-carboxylic Acid Ethyl Ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4-(3-Ethoxycarbonylpropionylamino)-2,6-dimethylisophthalic acid 1-ethyl ester: A stirred solution of 4-amino-2,6-dimethylisophthalic acid 1-ethyl ester (0.3 g, 1.26 mmol) and triethylamine (0.355 mL, 2.55 mmol) in dichloromethane (15 mL) at 0° C. is treated with ethyl succinyl chloride (0.199 mL, 1.39 mmol), and the reaction mixture is allowed to warm to room temperature overnight. The reaction mixture is washed with 1 M hydrochloric acid, back-washed with brine and dried over anhydrous MgSO4. The solvent is removed under reduced pressure to afford the title compound, which is used without further purification.

後処理

  1. washThe reaction mixture is washed with 1 M hydrochloric acid
  2. washback-washed with brine
  3. dry with materialdried over anhydrous MgSO4
  4. customThe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-597a5eed3804470c967de9592dc81776
出典データセット
uspto-grants-2013_10
特許番号
US08552015B2

反応ノート

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