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Glutaric anhydride → 4-[(4-Ethynylphenyl)carbamoyl]butanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Glutaric anhydride | HCID 7940 | — |
| 反応物 | 4-Ethynylaniline | HCID 3760025 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-[(4-Ethynylphenyl)carbamoyl]butanoic acid | HCID 24826477 | — |
反応手順
To a solution of 4-ethynylaniline (0.99 g, 8.5 mmol) in CH2Cl2 (100 ml) is added glutaric anhydride (1.06 g, 9.30 mmol). After 1 h, the resulting slurry is concentrated by rotary evaporation and the crude mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08552173B2 |
| 出典データセット | uspto-grants-2013_10 |
| ORD ID | ord-9e4878eddd2240059eb2c5c6c7987521 |
| 出典メモ | uspto-grants-2013_10 |