SS-3227 → (r)-1-[4-(2,3-Epoxypropoxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine

反応式

[F:1][C:2]([F:25])([F:24])[O:3][C:4]1[CH:23]=[CH:22][C:7]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)=[CH:6][CH:5]=1.[CH2:26](OS(C1C=CC([N+]([O-])=O)=CC=1)(=O)=O)[C@@H:27]1[O:29][CH2:28]1>>[O:29]1[CH2:28][C@@H:27]1[CH2:26][O:21][C:18]1[CH:19]=[CH:20][C:15]([N:12]2[CH2:11][CH2:10][CH:9]([O:8][C:7]3[CH:22]=[CH:23][C:4]([O:3][C:2]([F:1])([F:24])[F:25])=[CH:5][CH:6]=3)[CH2:14][CH2:13]2)=[CH:16][CH:17]=1

参加物

反応物 2

HCID 11653258SS-3227

HCID 14292098(R)-(-)-Glycidyl-4-nitrobenzenesulfonate

生成物 1

HCID 25121192(r)-1-[4-(2,3-Epoxypropoxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine

実験手順

A target compound was manufactured as in Example 1, using 4-[4-(4-trifluoromethoxyphenoxy)piperidin-1-yl]phenol and (R)-glycidylnosylate as starting raw materials.

出典と根拠

ORDレコード: ord-cb6794b165e44fa2bf5a6ab7021b3d30
出典データセット: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08552188B2

反応ノート

読み込み中…