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3-Hydroxy-3-phenyl-1-butyne → Mk-0873
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Hydroxy-3-phenyl-1-butyne | HCID 92098 | — |
| 反応物 | 1-(3-bromophenyl)-N-isopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide | HCID 12991318 | — |
| 反応物 | 3-Ethynyl-pyridine 1-oxide | HCID 56972334 | — |
| 生成物 | Mk-0873 | HCID 9919680 | — |
反応手順
Following the procedure of PREPARATIVE EXAMPLE 4, but substituting N-cyclopropyl-1-(3-bromophenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide from Step 1 of PREPARATIVE EXAMPLE 3 for N-isopropyl-1-(3-bromophenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide, and 3-ethynylpyridine N-oxide from Step 1 for 2-phenyl-3-butyn-2-ol, the N-cyclopropyl-1-[3-(1-oxido-3-pyridinylethynyl)phenyl]-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide compound was obtained as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08552193B2 |
| 出典データセット | uspto-grants-2013_10 |
| ORD ID | ord-a29c48a3bcfb4af18b2de81062da58a0 |
| 出典メモ | uspto-grants-2013_10 |