Methanesulfonyl chloride → (S)-tert-butyl 2-((S)-1,2-bis(tert-butyldimethylsilyloxy)ethyl)aziridine-1-carboxylate

温度

0 °C

A solution of tert-butyl (2S,3S)-3,4-bis(tert-butyldimethylsilyloxy)-1-hydroxybutan-2-ylcarbamate (1.025 g, 2.3 mmol) in 20 mL DCM was cooled to 0° C., treated with N,N-DIPEA (0.60 ml, 3.4 mmol) followed by Ms-Cl (0.18 ml, 2.3 mmol). After stirring at 0° C. for 2 hours, the reaction mixture was concentrated in vacuo and the crude residue was dissolved in 20 mL THF. KOt-Bu (0.51 g, 4.6 mmol) was added, and the reaction mixture was allowed to stir at RT for 10 minutes. The reaction mixture was then diluted with EtAOc, washed with water then brine. The organics dried over MgSO4 and concentrated in vacuo. Purification of the crude residue by column chromatography gave (5)-tert-butyl 2-((S)-1,2-bis(tert-butyldimethylsilyloxy)ethyl)aziridine-1-carboxylate as a clear oil.

1. concentrationthe reaction mixture was concentrated in vacuo
2. dissolutionthe crude residue was dissolved in 20 mL THF
3. stirringto stir at RT for 10 minutes
4. additionThe reaction mixture was then diluted with EtAOc
5. washwashed with water
6. dry with materialThe organics dried over MgSO4
7. concentrationconcentrated in vacuo
8. customPurification of the crude residue by column chromatography

ORDレコード

ord-63d965c1adbf4c96b152b2b607b5cdbc

出典データセット

uspto-grants-2013_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08552181B2