HCID 131730893、化合物 → 6-(Aminomethyl)-2,3-dihydro-1H-isoindol-1-one
反応式
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[CH2:14][NH:13][C:12]2=[O:18])CCC>Cl>[NH2:7][CH2:8][C:9]1[CH:10]=[C:11]2[C:15]([CH2:14][NH:13][C:12]2=[O:18])=[CH:16][CH:17]=1参加物
3
実験手順
A mixture of the product of Step 2 (100 g, 0.38 mol) and HCl (dissolved in MeOH, 3 M, 500 ml) was stirred overnight. Removal of the solvent gave a solid which was washed with Et2O and dried to afford 6-(aminomethyl)-2,3-dihydro-1H-isoindol-1-one (57 g, 76% yield). 1H-NMR (300 MHz, D2O) δ: 7.69-7.67 (m, 1H), 7.52 (s, 1H), 7.45-7.43 (m, 1H), 4.39 (s, 2H), 4.17 (s, 2H).
後処理
- customRemoval of the solvent
- customgave a solid which
- washwas washed with Et2O
- customdried
出典と根拠
- ORDレコード
- ord-c016de70aa044dca94f39155b2713a5a
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08551984B2
反応ノート
読み込み中…