Dichloromethane → 3-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol hydrochloride

HRID 1040302ノート

反応式

HRID 1040302 の反応式
[CH3:1][N:2]([CH3:16])[CH2:3][CH:4]([CH3:15])[CH:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7].[Cl:17]CCl>Cl.C(OC(C)C)(C)C>[ClH:17].[CH3:16][N:2]([CH3:1])[CH2:3][CH:4]([CH3:15])[CH:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7]

参加物

4

反応物 2

HCID 6344DichloromethaneHCID 64330913-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol

生成物 1

HCID 231069343-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol hydrochloride

試薬・触媒・溶媒 1

HCID 21510344Isopropyl ether hydrochloride溶媒

実験手順

To stirred solution of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (4 g, 0.02 mol) in dichloromethane (20 ml), isopropyl ether hydrochloride (6 ml) was added at ambient temperature and stirred for 30 minutes. Solvents were distilled off from the reaction mixture. To the residue isopropyl ether (8 ml) was added and stirred for 15 minutes. Solvent was distilled off from the mixture to give 4.3 g of the title compound.

後処理

  1. additionwas added at ambient temperature
  2. distillationSolvents were distilled off from the reaction mixture
  3. additionTo the residue isopropyl ether (8 ml) was added
  4. stirringstirred for 15 minutes
  5. distillationSolvent was distilled off from the mixture

出典と根拠

ORDレコード
ord-d3d93c13df264a87a63513b0942b1daf
出典データセット
uspto-grants-2013_10
特許番号
US08552219B2

反応ノート

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