Diethyl Ether → HCID 58430895、化合物

HRID 1040469ノート

反応式

HRID 1040469 の反応式
Cl.[CH:2]1([CH2:5]C(=N)OCC)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+].Cl.[NH2:18][CH2:19][C:20]#[N:21].[CH3:22][CH2:23][O:24]CC>O>[CH2:23]([O:24][C:5]([CH:2]1[CH2:3][CH2:4]1)=[N:21][CH2:20][C:19]#[N:18])[CH3:22]

参加物

6

反応物 4

HCID 3283Diethyl EtherHCID 11430Potassium CarbonateHCID 11491918Aminoacetonitrile hydrochlorideHCID 14860732Ethyl 2-cyclopropylethanecarboximidate hydrochloride

生成物 1

HCID 58430895HCID 58430895、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

To a suspension of ethyl cyclopropylacetimidate hydrochloride (6.0 g, 53 mmol) in ether (50 mL) was added anhydrous potassium carbonate (7.3 g, 53 mmol). After stirring for 5 min, a solution of aminoacetonitrile hydrochloride (4.9 g, 53 mmol) in water (40 mL) was added and the mixture stirred for additional 90 min. The reaction was diluted with water (100 mL) and extracted with ether (2×300 mL). The combined organic fractions were dried (Na2SO4), filtered, and concentrated to give N-cyanomethyl-cyclopropanecarboximidic acid ethyl ester as a liquid (4.54 g).

後処理

  1. stirringthe mixture stirred for additional 90 min
  2. extractionextracted with ether (2×300 mL)
  3. dry with materialThe combined organic fractions were dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-4068d6d00af54e1d8378c89ccb98a1f8
出典データセット
uspto-grants-2013_10
特許番号
US08552205B2

反応ノート

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