Hydrochloric Acid → 1-(Pyrimidin-2-yl)cyclopropan-1-amine dihydrochloride
反応式
C(OC(=O)[NH:7][C:8]1([C:11]2[N:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:18]>C(Cl)Cl>[ClH:18].[ClH:18].[N:12]1[CH:13]=[CH:14][CH:15]=[N:16][C:11]=1[C:8]1([NH2:7])[CH2:10][CH2:9]1参加物
4
実験手順
(1-Pyrimidin-2-yl-cyclopropyl)-carbamic acid tert-butyl ester (1.60 g, 6.80 mmol) was dissolved in CH2Cl2 (10 mL). HCl solution (4M in 1,4-dioxane, 17 mL, 68 mmol) was added via in one portion via syringe and the solution immediately became cloudy. The reaction was allowed to stir for 3 h. Solvents were removed in vacuo yielding a solid mass that was dried under vacuum to give 1.12 g of the title compound as a light yellow solid, m/z 136.32 [M+1]+.
後処理
- customSolvents were removed in vacuo
- customyielding a solid mass that
- customwas dried under vacuum
出典と根拠
- ORDレコード
- ord-2dfa6bf601e04eacb51e76a2e2a5ac12
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08552205B2
反応ノート
読み込み中…