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HRID 1041276作成日：2026年10月26日

2,4,5-Trichloropyrimidine → [2-(2,5-Dichloro-pyrimidin-4-ylamino)-3-methyl-phenoxy]-acetonitrile

https://huagongshe.com/reaction/1041276

反応式

関与物質

役割名称HCID仕込み量
反応物2,4,5-TrichloropyrimidineHCID 237259—
反応物(2-Amino-3-methyl-phenoxy)-acetonitrileHCID 43438079—
生成物[2-(2,5-Dichloro-pyrimidin-4-ylamino)-3-methyl-phenoxy]-acetonitrileHCID 86633985—

反応手順

[2-(2,5-Dichloro-pyrimidin-4-ylamino)-3-methyl-phenoxy]-acetonitrile was prepared from (2-Amino-3-methyl-phenoxy)-acetonitrile and 2,4,5-Trichloropyrimidine in an analogous manner to Example 1230a. Title product obtained as an off-white solid, 365 mg, 29%. MP: 134-136, LCMS 309.07 (M+H), HPLC purity 75%, 1H-NMR (CDCl3, 400 MHz) δ 8.20 (s, 1H), 7.31-7.27 (m, 1H), 7.07 (d, J=7.7 Hz, 1H), 6.95 (d, J=8.2 Hz, 1H), 6.82 (s, 1H), 4.79 (s, 2H), 2.27 (s, 3H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08552186B2
出典データセットuspto-grants-2013_10
ORD IDord-dfe390ada20648de8e7bad4b21f5158b
出典メモuspto-grants-2013_10