Sodium periodate → Tert-butyl (1-(2-(7-formyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate

HRID 1041965ノート

反応式

HRID 1041965 の反応式
I([O-])(=O)(=O)=O.[Na+].[OH:7][CH:8]([C:11]1[CH:16]=[CH:15][N:14]2[C:17]([C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[C:23]([N:30]5[CH2:35][CH2:34][CH:33]([CH2:36][NH:37][C:38](=[O:44])[O:39][C:40]([CH3:43])([CH3:42])[CH3:41])[CH2:32][CH2:31]5)[CH:24]=[CH:25][CH:26]=4)[N:21]=3)=[N:18][N:19]=[C:13]2[CH:12]=1)CO>C(Cl)Cl>[CH:8]([C:11]1[CH:16]=[CH:15][N:14]2[C:17]([C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[C:23]([N:30]5[CH2:31][CH2:32][CH:33]([CH2:36][NH:37][C:38](=[O:44])[O:39][C:40]([CH3:42])([CH3:41])[CH3:43])[CH2:34][CH2:35]5)[CH:24]=[CH:25][CH:26]=4)[N:21]=3)=[N:18][N:19]=[C:13]2[CH:12]=1)=[O:7]

参加物

4

反応物 2

HCID 23667635Sodium periodateHCID 86654349Tert-butyl (1-(2-(7-(1,2-dihydroxyethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate

生成物 1

HCID 86654350Tert-butyl (1-(2-(7-formyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a slurry of silica gel (0.1 g) in DCM (3 mL) was added sodium periodate (0.13 mL, 0.087 mmol). The reaction was stirred for 10 minutes. tert-Butyl (1-(2-(7-(1,2-dihydroxyethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate (30 mg, 0.058 mmol) in DCM (2 mL) was then added to the slurry. The reaction was stirred for 30 minutes, then filtered and washed with DCM (20 mL). The organic layer was concentrated to give crude product.

後処理

  1. stirringThe reaction was stirred for 30 minutes
  2. filtrationfiltered
  3. washwashed with DCM (20 mL)
  4. concentrationThe organic layer was concentrated
  5. customto give crude product

出典と根拠

ORDレコード
ord-f56aba911ee54afe88a3757b2b4dc2dd
出典データセット
uspto-grants-2013_10
特許番号
US08557809B2

反応ノート

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