関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | HCID 3973 | — |
| 反応物 | Methane, dichloromethoxy- | HCID 21004 | — |
| 生成物 | HCID 178478242 | HCID 178478242 | — |
反応手順
A solution of 2-morpholino-8-phenyl-4H-chromen-4-one (LY294002) (1.50 g, 4.93 mmol) and dichloromethyl methyl ether (15 mL) was stirred and heated to 80° C. for 2 hours under argon. The mixture was cooled to room temperature, and then concentrated in vacuo to give 4-chloro-2-morpholino-8-phenylchromenylium chloride (78) (2.06 g, 5.73 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08557807B2 |
|---|
| 出典データセット | uspto-grants-2013_10 |
|---|
| ORD ID | ord-46b2983438f841b6a62cea41dd274a12 |
|---|
| 出典メモ | uspto-grants-2013_10 |
|---|
