Water → 6-[(Methylsulfonyl)methyl]pyridin-3-yl benzenesulfonate

反応式

[C:1]1([S:7]([O:10][C:11]2[CH:12]=[N:13][C:14]([CH2:17]Br)=[CH:15][CH:16]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][S:20]([O-:22])=[O:21].[Na+].O>CN(C)C=O>[C:1]1([S:7]([O:10][C:11]2[CH:12]=[N:13][C:14]([CH2:17][S:20]([CH3:19])(=[O:22])=[O:21])=[CH:15][CH:16]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

実験手順

To a solution of 6-(bromomethyl)pyridin-3-yl benzenesulfonate (30 g) in N,N-dimethylformamide (200 mL) was added sodium methylsulfinate (11.2 g), and the mixture was stirred at room temperature for 15 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure to give the title compound (30 g, yield 100%) as white crystals.