Formic Acid → 7-Methyl-4(3H)-quinazolinone

HRID 1042253

反応式

HRID 1042253 の反応式
[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH:12](O)=O>>[CH3:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4](=[O:5])[NH:6][CH:12]=[N:1]2)=[CH:7][CH:8]=1

参加物

3

反応物 2

HCID 284Formic AcidHCID 28014742-Amino-4-methylbenzamide

生成物 1

HCID 1354525337-Methyl-4(3H)-quinazolinone収率 84.5%

反応条件

温度
100 °C

実験手順

A mixture of 2-amino-4-methylbenzamide (20 g, 133 mmol) and formic acid (120 ml, 3129 mmol) was heated to 100° C. for 6 h. The reaction was cooled to RT and the volatiles were removed under reduced pressure. The residue was then washed carefully with aqueous saturated sodium bicarbonate and then with water. The tan solid was then dried in a vacuum oven at 45° C. overnight to give 7-methylquinazolin-4(3H)-one (18.00 g, 84% yield). MS (ESI, pos. ion) m/z: 161 [M+H]+

後処理

  1. temperatureThe reaction was cooled to RT
  2. customthe volatiles were removed under reduced pressure
  3. washThe residue was then washed carefully with aqueous saturated sodium bicarbonate
  4. customThe tan solid was then dried in a vacuum oven at 45° C. overnight

出典と根拠

ORDレコード
ord-60582e02612445eba4e8741687084f5f
出典データセット
uspto-grants-2013_10
特許番号
US08557830B2

関連ノート

読み込み中…