Methanol → (2-Methoxy-3-methylphenyl)methanol

HRID 1042352

反応式

HRID 1042352 の反応式
[Li+].[BH4-].C[O:4][C:5](=O)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:7]=1[O:13][CH3:14].CO>CCOCC>[CH3:14][O:13][C:7]1[C:8]([CH3:12])=[CH:9][CH:10]=[CH:11][C:6]=1[CH2:5][OH:4]

参加物

5

反応物 3

HCID 887MethanolHCID 4148881Lithium borohydrideHCID 13229229Methyl 2-methoxy-3-methylbenzoate

生成物 1

HCID 53657677(2-Methoxy-3-methylphenyl)methanol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

LiBH4 (5.10 g, 0.23 mmol) was added to a solution of 2-methoxy-3-methyl-benzoic acid methyl ester (8.46 g, 47.00 mmol) in Et2O at 0° C. The reaction mixture was stirred for 5 minutes, MeOH (9.50 mL, 0.23 mmol) was added in a dropwise fashion. The reaction mixture was then stirred for 30 minutes, and was quenched into 1N NaOH. The resulting solution was extracted with Et2O (3×200 mL) and the combined organic phases were washed with brine (1×150 mL), dried over MgSO4 and concentrated to afford the title compound.

後処理

  1. stirringThe reaction mixture was then stirred for 30 minutes
  2. customwas quenched into 1N NaOH
  3. extractionThe resulting solution was extracted with Et2O (3×200 mL)
  4. washthe combined organic phases were washed with brine (1×150 mL)
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-d0d09a0335074675a496f017d1dd0309
出典データセット
uspto-grants-2013_10
特許番号
US08557853B2

関連ノート

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