化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → (3s,6r,7As)-6-amino-5-oxohexahydropyrrolizine-3-carbonitrile trifluoroacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Thioanisole | HCID 7520 | — |
| 反応物 | Tert-butyl ((2r,5s,7as)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate | HCID 91321587 | — |
| 生成物 | (3s,6r,7As)-6-amino-5-oxohexahydropyrrolizine-3-carbonitrile trifluoroacetate | HCID 11357934 | — |
反応手順
80 mg of tert-butyl ((2R,5S,7aS)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate were C reacted with 10% thioanisole in 1 ml of trifluoroacetic acid for 30 min. The solvents were then removed in vacuo, and the residue was stirred with diusopropyl ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094800B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-300496268f1a4ca7a2622d242dab1799 |
| 出典メモ | uspto-grants-2006_08 |