3-(Trifluoromethyl)phenyl isocyanate → 1-(4-Iodo-3-methylphenyl)-3-(3-(trifluoromethyl)phenyl)urea

HRID 1042653ノート

反応式

HRID 1042653 の反応式
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[CH3:9].[N:10]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=1)=[C:11]=[O:12].[N-]=C=O>C1C=CC=CC=1>[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:11]([NH:10][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:20])([F:21])[F:22])[CH:14]=2)=[O:12])=[CH:4][C:3]=1[CH3:9]

参加物

5

反応物 3

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 105034IsocyanateHCID 27342754-Iodo-3-methylaniline

生成物 1

HCID 684617451-(4-Iodo-3-methylphenyl)-3-(3-(trifluoromethyl)phenyl)urea

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
90 °C

実験手順

To a solution of 4-iodo-3-methylaniline (200 mg, 0.86 mmol) in benzene (5 mL) in a sealable tube was added 1-isocyanato-3-(trifluoromethyl)benzene (0.133 mL, 0.94 mL; “E” is an electrophilic group discussed in scheme 3, and here is an isocyanate). The tube was sealed and heated at 90° C. for 4 h. The mixture was allowed to cool to room temperature before filtering. The off white solid was washed with additional benzene (10 mL) and used without further purification.

後処理

  1. customThe tube was sealed
  2. temperatureto cool to room temperature
  3. filtrationbefore filtering
  4. washThe off white solid was washed with additional benzene (10 mL)
  5. customused without further purification

出典と根拠

ORDレコード
ord-098ec6bc6b8846d3a551d7c66a126e4c
出典データセット
uspto-grants-2013_10
特許番号
US08557996B2

反応ノート

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