1,3-Propanediamine, N1,N1,N3-trimethyl- → HCID 16109013、化合物
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5](F)=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[CH3:12][N:13]([CH3:19])[CH2:14][CH2:15][CH2:16][NH:17][CH3:18]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:17]([CH3:18])[CH2:16][CH2:15][CH2:14][N:13]([CH3:19])[CH3:12])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1参加物
3
実験手順
To a round bottom flask at 0° C. was added 4-Bromo-1-fluoro-2-nitrobenzene (10 g, 45.46 mmol) and N,N,N′-Trimethyl-propane-1,3-diamine (6.99 ml, 47.73 mmol). The reaction was allowed to warm to RT and stirred for 16 h. The reaction was extracted into EtOAc, washed once with saturated aqueous NaHCO3, twice with water, and then dried over Mg2SO4. The organic layer was filtered and concentrated to yield the title compound as a bright orange solid.
後処理
- extractionThe reaction was extracted into EtOAc
- washwashed once with saturated aqueous NaHCO3, twice with water
- dry with materialdried over Mg2SO4
- filtrationThe organic layer was filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a9fccb10f35a42358339b8bd56120457
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08557996B2
反応ノート
読み込み中…