Dimethyl Sulfoxide → N-(4-(7-(benzyloxy)-1,5-naphthyridin-4-yloxy)phenyl)-4-(4-chlorophenyl)phthalazin-1-amine

関与物質

役割	名称	HCID	仕込み量
反応物	Dimethyl Sulfoxide	HCID 679	—
反応物	Cesium carbonate	HCID 10796	—
反応物	3-(Benzyloxy)-8-chloro-1,5-naphthyridine	HCID 67316944	—
反応物	4-(4-(4-Chlorophenyl)phthalazin-1-ylamino)phenol hydrochloride	HCID 136381728	—
溶媒	Water	HCID 962	—
生成物	N-(4-(7-(benzyloxy)-1,5-naphthyridin-4-yloxy)phenyl)-4-(4-chlorophenyl)phthalazin-1-amine	HCID 67316920	—

反応条件

温度	100 °C

反応手順

A pyrex reaction tube was charged with 4-(4-(4-chlorophenyl)phthalazin-1-ylamino)phenol hydrochloride (344 mg, 894 μmol), 3-(benzyloxy)-8-chloro-1,5-naphthyridine (220 mg, 813 μmol), cesium carbonate (662 mg, 2032 μmol) and 4.1 mL DMSO. The tube was sealed and the mixture was heated at 100° C. for 4 h. Water was added and the resulting precipitate was filtered, washed with water and dried. The crude material was purified by silica gel chromatography, 90/10/1 DCM/MeOH/NH4OH in DCM to provide N-(4-(7-(benzyloxy)-1,5-naphthyridin-4-yloxy)phenyl)-4-(4-chlorophenyl)phthalazin-1-amine. MS: [M+H]=583.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08557816B2
出典データセット	uspto-grants-2013_10
ORD ID	ord-feef8d88f49a483fbc081a34d291477a
出典メモ	uspto-grants-2013_10