Piperazine → 2-[1-(4-Methoxy-benzyl)-1h-benzotriazol-4-yloxy]-4-piperazin-1-yl-benzoic acid methyl ester

HRID 1043172ノート

反応式

HRID 1043172 の反応式
[CH3:1][O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][C:7](F)=[CH:6][C:5]=1[O:11][C:12]1[C:20]2[N:19]=[N:18][N:17]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=3)[C:16]=2[CH:15]=[CH:14][CH:13]=1.[NH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1.ClCCl>CS(C)=O>[CH3:1][O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][C:7]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[CH:6][C:5]=1[O:11][C:12]1[C:20]2[N:19]=[N:18][N:17]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=3)[C:16]=2[CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 4837PiperazineHCID 6344DichloromethaneHCID 672269974-Fluoro-2-[1-(4-methoxy-benzyl)-1h-benzotriazol-4-yloxy]-benzoic acid methyl ester

生成物 1

HCID 672279252-[1-(4-Methoxy-benzyl)-1h-benzotriazol-4-yloxy]-4-piperazin-1-yl-benzoic acid methyl ester

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
100 °C

実験手順

To a solution of EXAMPLE 342D (650 mg) in dimethylsulfoxide (12 mL) was added piperazine (618 mg). The solution was heated at 100° C. for one hour, cooled, added to dichloromethane, extracted with water three times, dried over anhydrous sodium sulfate, filtered, and the solvent was removed under vacuum.

後処理

  1. temperaturecooled
  2. extractionextracted with water three times
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customthe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-0e75cda1114c439eaa8d034534237606
出典データセット
uspto-grants-2013_10
特許番号
US08557983B2

反応ノート

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