Potassium Hydroxide → potassium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

HRID 1043332ノート

反応式

HRID 1043332 の反応式
[CH3:1][C:2]1([CH3:11])[O:6][C@@H:5]([C:7]([O:9]C)=[O:8])[CH2:4][O:3]1.[OH-].[K+:13]>CO.CCOCC>[K+:13].[CH3:1][C:2]1([CH3:11])[O:6][C@@H:5]([C:7]([O-:9])=[O:8])[CH2:4][O:3]1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 853166Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

生成物 1

HCID 23678350potassium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate収率 94%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

To a solution of methyl(R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (0.16 mL, 1.0 mmol) in MeOH (2 mL), 2 N KOH (0.5 mL, 1 mmol) was added. The resulting solution was stirred at RT for 20 min and concentrated in vacuo. The residue obtained was suspended in ether (10 mL) and sonicated for 5 min. The ether was then removed and the resulting residue was dried in vacuo for 4 h to obtain (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid potassium salt (173 mg, 94%) which was directly used in the next step without purification.

後処理

  1. concentrationconcentrated in vacuo
  2. customThe residue obtained
  3. customsonicated for 5 min
  4. customThe ether was then removed
  5. customthe resulting residue was dried in vacuo for 4 h

出典と根拠

ORDレコード
ord-5517b33923f34e69868809923bb1740a
出典データセット
uspto-grants-2013_10
特許番号
US08557847B2

反応ノート

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