Ammonia → 5-Aminouracil

HRID 1043555

反応式

HRID 1043555 の反応式
N.[N+:2]([C:5]1[C:6](=[O:12])[NH:7][C:8](=[O:11])[NH:9][CH:10]=1)([O-])=O>O>[NH2:2][C:5]1[C:6](=[O:12])[NH:7][C:8](=[O:11])[NH:9][CH:10]=1

参加物

4

反応物 2

HCID 222Ammonia2 回HCID 691355-Nitrouracil

生成物 1

HCID 136115-Aminouracil

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
75 °C

実験手順

Into a 5-L 4-necked round-bottom flask were placed water (2.871 L), ammonia (116.1 mL) and 5-nitropyrimidine-2,4(1H,3H)-dione (180 g, 1.15 mol, 1.00 equiv). This was followed by the addition of Na2S2O2 (860 g, 6.06 mol, 4.30 equiv) in several batches. The pH value of the solution was adjusted to 8 with ammonia (25%). The resulting solution was stirred for 3 h (hours) at 75° C. The reaction mixture was cooled to 15° C. with an ice/water bath. The solid was collected by filtration. This resulted in 118 g (81%) of 5-aminopyrimidine-2,4(1H,3H)-dione 1 as a yellow solid (see Scheme 1).

後処理

  1. customInto a 5-L 4-necked round-bottom flask were placed
  2. temperatureThe reaction mixture was cooled to 15° C. with an ice/water bath
  3. filtrationThe solid was collected by filtration
  4. customThis resulted in 118 g (81%) of 5-aminopyrimidine-2,4(1H,3H)-dione 1 as a yellow solid (see Scheme 1)

出典と根拠

ORDレコード
ord-806d22519b394529a2a8b4188d7e8cb7
出典データセット
uspto-grants-2013_10
特許番号
US08563540B2

関連ノート

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