Hydrochloric Acid → 4-(Azetidin-3-yl)morpholine

HRID 1043595ノート

反応式

HRID 1043595 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH:7]2[CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]2)[CH2:3][CH2:2]1.Cl.O1CCOCC1>C(Cl)Cl>[NH:9]1[CH2:10][CH:7]([N:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)[CH2:8]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 673432951-Azetidinecarboxylic acid, 3-(4-morpholinyl)-, 1,1-dimethylethyl ester

生成物 1

HCID 134019734-(Azetidin-3-yl)morpholine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

tert-butyl 3-morpholinoazetidine-1-carboxylate (31 mg) was treated with 4N HCl in dioxane (5 eq) in 1 mL of DCM. The reaction mixture was stirred for 3 hours at room temperature and then concentrated to dryness to yield 4-(azetidin-3-yl)morpholine in quantitative yield. 4-(6-(Bromomethyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine 7 (0.413 g) was reacted with 4-(azetidin-3-yl)morpholine via General Procedure B to afford 0.4 g 4-(1-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)azetidin-3-yl)morpholine

後処理

  1. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-309413e2bf43418b89b327ce5a9cd8ce
出典データセット
uspto-grants-2013_10
特許番号
US08563540B2

反応ノート

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