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3-Methoxyaniline → 3-(3-Methoxy-phenylamino)-2-nitro-propenal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methoxyaniline | HCID 10824 | — |
| 反応物 | Nitromalonaldehyde | HCID 313475 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(3-Methoxy-phenylamino)-2-nitro-propenal | HCID 72168497 | 78.4% |
反応手順
To the HCl salt of 3-methoxy-phenylamine (4.6 g, 289 mmol) in 1N HCl (300 mL) was added a solution of 2-nitro-malonaldehyde (2.7 g, 19.3 mmol) in 150 mL water. After 30 min, the precipitate was filtered and rinsed with 0.1 N HCl. Air-drying in a Büchner funnel for 18 h gave 3.36 g (78%) of a light yellow/green powder. LC/MS (m/z): 245.1 (MH++Na), Rt 2.21 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08563549B2 |
| 出典データセット | uspto-grants-2013_10 |
| ORD ID | ord-267e3a3b405d49379730e5b3a6450501 |
| 出典メモ | uspto-grants-2013_10 |