Phthalamide → 2-[3-(4-Fluoro-phenyl)-2-oxo-propyl]-isoindole-1,3-dione

HRID 1043844

反応式

HRID 1043844 の反応式
Cl[CH2:2][C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1.[K].[C:14]([NH2:25])(=[O:24])[C:15]1[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:17](N)=[O:18]>CN(C=O)C>[F:11][C:8]1[CH:9]=[CH:10][C:5]([CH2:4][C:3](=[O:12])[CH2:2][N:25]2[C:14](=[O:24])[C:15]3[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:17]2=[O:18])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 6956PhthalamideHCID 5462222PotassiumHCID 135582931-Chloro-3-(4-fluorophenyl)propan-2-one

生成物 1

HCID 581269722-[3-(4-Fluoro-phenyl)-2-oxo-propyl]-isoindole-1,3-dione

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of the product of example 35 (85 mg, 0.45 mmol) in DMF (1 mL), under a nitrogen atmosphere, was added potassium salt of phthalamide (96 mg, 0.52 mmol). The resulting mixture was stirred at room temperature for 1 h. The reaction mixture was quenched with a mixture of ice-water and filtered. The slightly pink solid was washed with water to give the titled compound as a white product (79 mg, 62% yield).

後処理

  1. customThe reaction mixture was quenched with a mixture of ice-water
  2. filtrationfiltered
  3. washThe slightly pink solid was washed with water

出典と根拠

ORDレコード
ord-c16cf46b15c440a1983537962a462515
出典データセット
uspto-grants-2013_10
特許番号
US08563562B2

関連ノート

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