1,4-Dioxane hydrochloride → (3SR,4RS)-4-hydrazinyltetrahydrofuran-3-ol hydrochloride

HRID 1043885ノート

反応式

HRID 1043885 の反応式
O1CCOCC1.[ClH:7].[OH:8][CH:9]1[CH2:13][O:12][CH2:11][CH:10]1[NH:14][NH:15]C(OC(C)(C)C)=O>CO>[ClH:7].[NH:14]([CH:10]1[CH2:11][O:12][CH2:13][CH:9]1[OH:8])[NH2:15]

参加物

4

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86686323t-butyl 2-((3RS,4SR)-4-hydroxytetrahydrofuran-3-yl)hydrazinecarboxylate

生成物 1

HCID 86686324(3SR,4RS)-4-hydrazinyltetrahydrofuran-3-ol hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A 4 M hydrogen chloride-1,4-dioxane solution (50 mL) was added to a solution of t-butyl 2-((3RS,4SR)-4-hydroxytetrahydrofuran-3-yl)hydrazinecarboxylate (5.78 g) in methanol (30 mL) under ice-cooling, and the mixture was then warmed to room temperature and stirred overnight. The reaction mixture was concentrated to give the title compound (5 g).

後処理

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated

出典と根拠

ORDレコード
ord-2a0fc353c9dd48bfa2d7ccc7df69d076
出典データセット
uspto-grants-2013_10
特許番号
US08563565B2

反応ノート

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