Tetrabutylammonium Fluoride → 3-Bromo-2-(fluoromethyl)-6-methoxy-4-methylpyridine
反応式
[Br:1][C:2]1[C:3]([CH2:11]Br)=[N:4][C:5]([O:9][CH3:10])=[CH:6][C:7]=1[CH3:8].CCCC[N+](CCCC)(CCCC)CCCC.[F-:30]>>[Br:1][C:2]1[C:3]([CH2:11][F:30])=[N:4][C:5]([O:9][CH3:10])=[CH:6][C:7]=1[CH3:8]参加物
3
実験手順
A mixture of 3-bromo-2-(bromomethyl)-6-methoxy-4-methylpyridine (126 mg) and TBAF (1.71 mL, 1 M solution in THF) was stirred at room temperature for two hours. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%) to give the title compound (37 mg).
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe resulting residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%)
出典と根拠
- ORDレコード
- ord-6be50967bf7f4a1a9d22e9f549658854
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08563565B2
反応ノート
読み込み中…