Dimethylformamide → 3-Bromo-5-fluoro-2-methoxy-4-methylpyridine

HRID 1043919ノート

反応式

HRID 1043919 の反応式
[Br:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[CH3:8].CN([CH:14]=[O:15])C.C[O-].[Na+]>O>[Br:1][C:2]1[C:3]([O:15][CH3:14])=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[CH3:8]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 10942334Sodium MethoxideHCID 73555087HCID 73555087、化合物

生成物 1

HCID 866863433-Bromo-5-fluoro-2-methoxy-4-methylpyridine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

3-bromo-2-chloro-5-fluoro-4-methylpyridine (340 mg) was added to DMF (1.8 mL). Sodium methoxide (28% solution in methanol, 5.4 mL) was added to the solution, and the mixture was stirred at 80° C. for two hours. Water was added to the reaction mixture. The precipitated solid was collected by filtration to give the title compound (240 mg).

後処理

  1. filtrationThe precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-ad0a96bf3f0247ac90b793971266620f
出典データセット
uspto-grants-2013_10
特許番号
US08563565B2

反応ノート

読み込み中…