4-Bromophenol → 2-(4-Bromophenoxy)-1-methyl-1H-benzo[d]imidazole
反応式
Cl[C:2]1[N:6]([CH3:7])[C:5]2[CH:8]=[CH:9][CH:10]=[CH:11][C:4]=2[N:3]=1.[CH:12]1[C:17]([OH:18])=[CH:16][CH:15]=[C:14]([Br:19])[CH:13]=1>C(N(CC)CC)C>[Br:19][C:14]1[CH:15]=[CH:16][C:17]([O:18][C:2]2[N:6]([CH3:7])[C:5]3[CH:8]=[CH:9][CH:10]=[CH:11][C:4]=3[N:3]=2)=[CH:12][CH:13]=1参加物
4
反応条件
- 温度
- 120 °C
実験手順
Triethylamine (18 ml) was added to a mixture of 2-chloro-1-methyl-1H-benzimidazole (7.2 g) and p-bromophenol (22.5 g) at room temperature. The mixture was stirred at 120° C. for 6 h. The mixture was quenched with water at room temperature and extracted with EtOAc. The organic layer was separated, washed with 1 N NaOH aq. and brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by column chromatography (NH silica gel, eluted with 10%-15% EtOAc in hexane) to give 2-(4-bromophenoxy)-1-methyl-1H-benzimidazole (3.2 g) as colorless crystals.