Thiophenol → S-Phenyl 2-(2-naphthyl)ethanethioate

HRID 1044433

反応式

HRID 1044433 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C:12](Cl)=[O:13].C(N(CC)CC)C.[C:22]1([SH:28])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.CCCC(C)C.C(OCC)(=O)C>C1(C)C=CC=CC=1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C:12](=[O:13])[S:28][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

6

反応物 4

HCID 7969ThiophenolHCID 8471TriethylamineHCID 5881152-(2-Naphthyl)acetyl chlorideHCID 21882781Isohexane ethyl acetate

生成物 1

HCID 86656471S-Phenyl 2-(2-naphthyl)ethanethioate収率 90%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

2-(2-Naphthyl)acetyl chloride (308 mg, 1.5 mmol) in 4.5 mL toluene was added to a solution of triethylamine (0.21 mL, 1.5 mmol) and thiophenol (153 μL, 1.5 mmol) in 3 mL toluene. Reaction monitoring was accomplished by TLC: iso-hexane/ethyl acetate 25:1, Rf=0.33. Workup yielded 376 mg (90%) S-phenyl 2-(2-naphthyl)ethanethioate 9 as yellow solid.

後処理

  1. customReaction monitoring

出典と根拠

ORDレコード
ord-72f8aa65196b4fac9589f9473775982e
出典データセット
uspto-grants-2013_10
特許番号
US08563598B2

関連ノート

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